Saturday, June 4, 2011

New strain of MRSA found in cows

2 June 2011 Last updated at 23:39 GMT Pallab Ghosh By Pallab Ghosh Science correspondent, BBC News MRSA Dr Garcia-Alvarez said finding a new strain in both in humans and cows is 'very worrying' A new strain of the MRSA "superbug" has been found in British cows and is believed to be infecting humans.

Environmental campaigners say the new strain has emerged because of the over-use of antibiotics by dairy farmers.

Dr Mark Holmes of Cambridge University, who led the research, said this was a "credible hypothesis".

The researchers, writing in the Lancet Infectious Diseases Journal, say there is no additional health risk from eating milk and dairy products.

'Financial pressure'

MRSA, or methicillin-resistant Staphylococcus aureus, is a drug-resistant form of a usually harmless bacterium which can be deadly when it infects wounds.

The 35 or so strains of antibiotic-resistant superbugs are genetically fairly similar. However, this new variety is very different and it is thought that it might have first emerged from cows.

Its discoverers have dubbed it "New MRSA"

Antibiotics are widely used by dairy farmers to treat cows with mastitis. However over-use means some bacteria become resistant and difficult to treat if humans become infected.

Dr Holmes said the problem might be exacerbated by financial pressures on diary farmers.

"If you drive your cows harder to produce more milk you get more mastitis," he told reporters at a news conference.

The Soil Association has called for a complete ban on routine use of antibiotics in farming.

Soil Association director Helen Browning said: "Dairy systems are becoming ever more antibiotic-dependent. We need to get farmers off this treadmill, even if that means that milk has to cost a few pennies more".

National Farmers' Union chief dairy adviser Rob Newberry said the health and welfare of cows were of "paramount importance" to British dairy farmers.

"In the interests of human and animal health, and animal welfare, it is important that veterinary medicines are administered as little as possible but as much as necessary," he said.

"Any antibiotic or veterinary medicine being administered to a food producing animal has strict conditions of use, including milk and meat withdrawal times, and in general, under European law, would only be available under prescription."

Dr Holmes and his colleague Dr Laura Garcia-Alvarez discovered the new strain while studying a bacterium known to cause mastitis in cows.

They found that, like other MRSA strains, it was resistant to the most commonly used antibiotics. However, the bug was found to be genetically very different.

Subsequent research showed that the strain was also present in humans.

Dr Garcia-Alvarez says that finding a new strain in both in humans and cows is "very worrying".

"Workers on dairy farms are at higher risk of carrying MRSA but we don't yet know if this translates to a higher risk [of them becoming ill]," she said.

'Very low risk'

Dr Holmes said very few people had been infected with the new strain, probably fewer than 100 a year in the UK. "But it does appear that the numbers are rising," he says.

The Health Protection Agency said the risk of becoming infected with the new strain was "very low".

Dr Holmes and Dr Garcia-Alvarez will now investigate the prevalence of the new strain and whether it is more or less harmful than current strains.

They also plan to conduct studies on farms to look for more MRSA strains of this type and explore any potential risks to farm workers.

MRSA is often found in hospitals and was linked to 1,593 deaths in 2007.

Since then the number of suspected fatal cases has fallen dramatically. There were 1,290 in 2008 and 781 in 2009.

A Department of Health spokesman said: "From the available evidence, we understand this new form of MRSA is rare in the UK and is not causing infections in humans.

"However, our expert committee, ARHAI, will be reviewing this issue at their next meeting and will consider potential medical, veterinary and food safety issues."

A Food Standards Agency spokesman said the study did not provide direct evidence that humans were being infected with MRSA from cattle.

"The risk of contracting this new strain of MRSA through drinking milk is extremely low because the vast majority of cows' milk is pasteurised and the pasteurisation process destroys all types of MRSA," he added.


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Is SPF15 cream strong enough to give protection?

1 June 2011 Last updated at 07:04 GMT By James Gallagher Health reporter, BBC News Sun cream being applied What strength sun cream should be used? People should use stronger sun cream to protect against cancer, a medical journal has warned.

Guidelines from the National Institute for Health and Clinical Excellence (NICE) stated that "SPF 15 is sufficient if applied adequately".

However, the Drug and Therapeutics Bulletin argued that few people apply enough sun cream, and that SPF 30 should be recommended instead.

NICE said the guidelines were balanced and for England, not hotter climates.

Ultraviolet (UV) radiation damages the skin and increases the risk of developing skin cancer.

Sun cream acts as a protective layer, preventing the damaging radiation from reaching the skin.

Research has shown that SPF 15 is strong enough if it is applied thickly. The standard is set at 2 mg/cm?. For an adult that works out at about a sixth of a 200ml bottle to cover the whole body.

Yet many people apply much less, between 0.4 and 1.5 mg/cm?.

'Blunder'

The study said that in reality people were getting "no more than half, at best, of the protection indicated by the labelled SPF".

Labelled sun cream SPF Effective SPF at 1.5 mg/cm? Effective SPF at 0.5 mg/cm?

Dr Ike Iheanacho, the editor of Drug and Therapeutics Bulletin, said: "NICE's recommendation to use sunscreens with an SPF as low as 15 is a blunder that overlooks the key evidence and is not in the best interests of public health.

"This advice needs urgent review and correction."

The journal recommended that: "Products labelled with an SPF of 30 will more reliably deliver adequate sun protection to most people who use sunscreens and would be sufficient to prevent sunburn under most circumstances."

Baby with sun cream Sun cream is less effective if applied too thinly

Professor Mike Kelly, director of the Centre for Public Health Excellence at NICE, said: "The NICE guidance referred to was not an assessment of which sun protection factor is optimal, but rather was concerned with the most effective ways of reducing skin cancer in England through provision of information, supply of resources and changes to the physical environment.

"It also sought to make clear that sunshine can be good for us, in that it provides a good source of vitamin D, and the opportunity to be physically active out of doors.

"We felt it was important, in producing this guidance, to maintain a balance - recognising on the one hand the very real dangers of skin cancer, but also remembering on the other hand that we should not extrapolate from research carried out in much hotter, sunnier climates than our own.

"We commissioned an expert report on the use of sunscreen in preventing skin cancer in England. According to this evidence, which was presented to the committee, SPF 15 should be sufficient as long as it is applied adequately.

"However, the guidance also acknowledges that to take account of people not applying sufficient quantities of sunscreen, SPF 30 was also recommended in an expert paper."


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Care regulator has staff shortage

3 June 2011 Last updated at 15:11 GMT Carer and patient Serious concerns have been raised over the care industry England's care home regulator has a staff shortage of nearly 300, including some 133 inspectors, it has said.

The Care Quality Commission (CQC) has 283 unfilled posts in its workforce, including inspectors whose job it is to ensure care homes meet standards.

It blamed a recruitment freeze imposed by the Government last year - but the Department of Health said it relaxed the curb in February.

Charities have expressed concern at news of the shortfall.

Shadow health and social care minister Emily Thornberry said she wrote to Health Minister Paul Burstow on Friday to ask for an independent inquiry into whether the CQC had sufficient powers and resources.

"It's a matter of great concern that, at a time when the work of the CQC is set to increase sharply and when care services are under such stress as a result of government cutbacks, that it can be 133 inspectors short," she added.

News of the shortfall, initially reported by the Financial Times, comes after serious questions were raised over the care industry, as abuse at the Winterbourne View home for learning disabilities sufferers and financial problems at Southern Cross care homes came to light.

Southern Cross, Britain's largest care home provider, has delayed rent payments to its landlords in an effort to fend off bankruptcy.

Secret filming by BBC Panorama, broadcast on Tuesday, found a pattern of serious abuse at Winterbourne View.

'Unreserved apology'

The regulator said that following an internal review it recognised that "there were indications of problems at this hospital which should have led to us taking action sooner".

It offered an "unreserved apology" after admitting it failed to respond to at least two warnings from a former nurse at the centre in Bristol.

The Government has ordered a report into the abuse.

An inspector working for the CQC has told the Daily Mail the regulator was understaffed and unable to make the necessary inspections.

The inspector said checks on hospitals had been sidelined and the CQC was "completely hampered by bureaucracy and red tape".

Fully accountable

Mark Milton, chief operating officer of the National Autistic Society, said: "We are extremely concerned that there have been 70% fewer inspections of adult care services in the past year, which may be partly attributable to a lack of inspection staff.

"The horrifying abuse uncovered by Panorama shows a clear need for robust regulation, as well as high-quality commissioning and the development of a culture within organisations of zero tolerance of abuse.

"We are calling on the government to ensure that the CQC is properly resourced to provide a fully accountable regulatory system that protects the vulnerable people that we all trust in them to support."

David Congdon, head of campaigns and policy at Mencap, said: "The government must look at investing money into the sector to ensure the safety and quality of life of some of society's most vulnerable."

A spokeswoman for the Royal College of Nursing said the CQC needed to demonstrate it was a "robust regulator with real teeth".

"Clearly it has some urgent work to do to make certain that it can fulfil this important role - and this includes the proper resources to enable it to deliver," the spokeswoman added.

The CQC said its inspection rate had fallen while it assessed care providers as part of a new system - but they were now on the rise again.

It said it was "committed" to effective regulation.

A spokeswoman said: "The CQC has had a recruitment freeze imposed on it after the election which has only just been raised and we are beginning to recruit frontline staff."

A Department of Health spokesman said the recruitment freeze was relaxed in February and it approved the recruitment of 75 inspectors in October

"The hiring of inspectors and staff is the direct responsibility of the CQC," a spokesman added.


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Friday, June 3, 2011

New York wants fizzy drink ban

Dave Howard By Dave Howard
Newsbeat US reporter Fizzy drink cans With a month to go before the height of summer, temperatures in New York are already hitting 30C (86F).

For Dennis, Johnson and Javii, playing basketball in the Bronx, it's the kind of weather for a refreshing fizzy drink.

"Soda's good for us," says Johnson.

Dennis is even sure fizzy drinks can help with medical problems: "If you have a stomach ache," he says, "What does your mom buy?"

He answers his own question: "Ginger ale, right? That's a soda."

Twenty-three-year-old Dominique Pleasant is sitting nearby with her two daughters. They're all drinking cans of cola.

Like more than a quarter of people in the Bronx, Dominique qualifies for food stamps.

"Food stamps is free money from the government to purchase food," she explains.

"It's for people on low incomes, single parent families like us or people that don't have a job."

'It's stupid'

It's estimated 1.7 million New Yorkers claim food stamps.

Now the city's waiting to hear if the federal government in Washington will allow a ban on spending food stamps on fizzy drinks.

Dennis, Johnson and Javii Dennis, Johnson and Javii enjoy a fizzy drink while playing basketball

Health officials say it's to cut obesity and tackle illnesses like diabetes.

"I think it's stupid," says Dominique. "It makes no sense. The air we are breathing is bad but they aren't trying to stop that."

New York has seen a long line of moves lately to try to improve public health.

It's just banned smoking in public parks. Chain restaurants have to put calorie counts on menus.

There's been a series of hard-hitting adverts on local TV warning of the dangers of fizzy drinks.

Officials say it's about helping people make the right choices.


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Fear 'worsens' cardiac outcome

1 June 2011 Last updated at 22:35 GMT Patient in cardiac intensive care - file photo Some patients express a fear of dying during a heart attack People with an intense fear of dying during a heart attack could suffer a worse outcome, research suggests.

London-led researchers asked 208 patients to rate their levels of fear following a severe cardiac event.

People who reported they were most distressed during an attack had higher levels of chemical markers - linked to inflammation - in their blood.

Writing in the European Heart Journal, the authors say heightened inflammation may lead to poorer long-term health.

"Large inflammatory responses are known to be damaging to the heart, and to increase the risk of longer-term cardiac problems such as having another heart attack, " said British Heart Foundation professor of psychology, Andrew Steptoe.

The research, led by a team at Imperial College, found that patients who reported an intense fear of dying had raised levels of TNF alpha - a marker that has been linked to inflammatory processes in the body.

Continue reading the main story
This study suggests that people who are most distressed during a heart attack have higher levels of particular chemical markers in their blood”

End Quote Dr Mike Knapton British Heart Foundation They also measured heart rate variability and the stress hormone cortisol, three weeks after the event.

Professor Steptoe, who worked on the study, said: "Fear of dying is not just an emotional response, but is linked into the biological changes that go on during acute cardiac events.

"This is an observational study, so we do not know whether helping people overcome their fears would improve the clinical outlook."

Dr Mike Knapton, associate medical director at the British Heart Foundation, said: "This study suggests that people who are most distressed during a heart attack have higher levels of particular chemical markers in their blood, which are associated with greater inflammation in the body.

"Inflammation has previously been linked with an increased risk of heart attack but we don't yet fully understand why.

"What we need to know now is whether we can allay people's fears at the time of a heart attack and whether this actually translates into better outcomes in the long term."


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Enzyme offers Huntington's hope

3 June 2011 Last updated at 01:00 GMT Fruit fly eye and body Researchers reduced the death of neurons in fruit flies by blocking a particular enzyme. A new approach to treating Huntington's disease may have been found, a UK study carried out in fruit flies suggests.

The incurable disease, caused by degeneration of nerve cells, gradually impairs a person's ability to function.

Researchers slowed the development of neurodegeneration - a key factor in Huntington's disease - by targeting a particular enzyme in fruit-flies.

The study, led by the University of Leicester, is published in Current Biology.

"This breakthrough is important as no drugs currently exist that halt progression, or delay onset of Huntington's disease," said Dr Giorgini, who led the study.

The researchers found decreasing the activity of a certain enzyme - known as KMO - reduced the number of neurons dying in the fruit-flies.

"Since we have identified an actual target and there are chemicals that can act on the target, there is a possibility that we could develop drugs to delay the onset of the disease," Dr Giorgini said.

Scientists also found that targeting other related enzymes with chemicals improved Huntington's symptoms in fruit flies.

"We would like to look in closer detail at the other enzymes in the same pathway and to develop new inhibitors of KMO," Dr Giorgini said.

Brain inflamation

Research from America also suggests the enzyme could be a key target for therapies.

The US research, published in Cell, found symptoms of Huntington's disease in mouse models could be reduced by blocking the same enzyme.

They developed a new compound - known as JM6 - that blocks the enzyme, leading to reduced brain inflammation in mice.

Working with mouse models of another neurodegenerative condition - Alzheimer's disease - they found that JM6 also prevents memory loss.

"The discovery has significant implications for two devastating diseases and suggest that the KMO enzyme is a good protein for us to target with medications in diverse neurodegenerative disorders," said Professor Lennart Mucke, of the Gladstone Institute, where the research took place.

Huntington's Disease Association chief executive Cath Stanley said: "This is an exciting piece of research that will offer hope to the many people affected by Huntington's disease."


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Food for thought

31 May 2011 Last updated at 16:42 GMT By Stephen Evans BBC News, Berlin Spanish cucumbers, file pic German officials say they are no longer sure Spanish cucumbers are the source of the outbreak One of the mysteries about the outbreak of the particularly vicious strain of E. coli is that most of the victims have been women.

In most outbreaks, the victims are children because they have not developed the immune system to fight off the food poisoning - but in the German case, it is adults and female adults, in particular.

Scientists simply do not know why.

One theory was that the victims were often people who liked eating what they thought was healthy food, say because it was low calorie (like cucumbers) or because it was organic.

But the scientists are now cautioning against that view. It may be too pat.

Dr Ulf Goebel of the Charite university hospital in Berlin said it might just be that this specific strain had something in it which found women's bodies suitable and not men's (just as some strains work on some ethnic groups and not others).

Intriguingly, a previous outbreak of this rare type of E. coli happened in the United States in 1994 - and again the victims were predominantly women, with the average victim being 36 years of age.

DNA tests

If it is simply that women are more susceptible to this particular type of E. coli, then that would point away from the "health food" theory.

Continue reading the main story
It's a good idea to wash fruit and vegetables before you eat them to ensure that they are clean, and to help remove germs that might be on the outside ”

End Quote As if to confuse matters further, the German authorities, having pointed the finger at Spain earlier, said tests on the suspect cucumbers had shown a trace of a different strain of E. coli - in other words: the cucumbers were not guilty of causing the current outbreak.

All this matters greatly because once a country's farms are tainted, trade collapses. Information affects livelihoods, which explains the outrage in Spain at German accusations.

There is some dismay in other cucumber-growing countries too.

A lack of clarity serves to put a cloud of suspicion over many. Some consumers simply shy away from the suspect vegetable without making a distinction about source.

So the task of getting clarity is urgent.

There is an immense amount of extraordinarily clever work going into identifying the source, like studying the DNA of the bacterium.

But the true breakthrough will come, Dr Goebel says, through what amounts to detective work: simply asking all the surviving victims what they ate and when they ate it, and then comparing notes to find a pattern.

Simple, really - or not.

Consumers told not to eat cucumbers, lettuces and raw tomatoes. 1,150 cases of E.coli confirmed; 14 deaths

One death and 36 suspected E. coli infections, linked to travel in northern Germany.

Top European cucumber producer - threatens to seek compensation from the European Union for lost vegetables sales

Ban on all imports of cucumbers, tomatoes and fresh salad from Spain and Germany pending further notice

Some Spanish-grown cucumbers removed from sale

Some Spanish-grown cucumbers removed from sale

Ban on sale of cucumbers, tomatoes and aubergines imported via Germany

Reported to have banned cucumber imports from Spain

Halted all cucumber shipments to Germany

Testing cucumbers for contamination


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